Pandas Data Frame Select column last value and replace with blank

Question

I have a data frame with lots of columns, I wanted to replace the last value of few of columns with blank, what is the best way to do that.

the thing is data frame can be dynamic with values and length.

Here is the data frame:

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How can I remove values from column F and G to blank?

please except typos as I'm new here.

Answer 1

df.loc[df.index[-1], ['G', 'F']] = np.nan