CODEWITHSUNDEEP
rcox-regressioncox
imunicorn
imunicorn

Reputation: 1

Error fitting a proportional hazards regression model to case-cohort data with cch function

I am trying to fit a proportional hazards regression model to case-cohort data (where cases are oversampled and not representative of the population). I am using the Survival package and cch() function.

fit <- cch(Surv(followuptime, event) ~ A1 + A2 + A3, data =datadf, stratum=NULL, subcoh = datadf$subcoh, id=datadf$id, cohort.size=4512, method="Prentice")

The A1, A2, A3 are metabolites, and I have 812 of them. When I fit the model with ~40 of them it works. But when I fit with more, I keep running into one of the following errors. I have no idea how to fix it and I would appreciate any help!

Error in if (any(exp(temp) > .Machine$double.xmax) || all(exp(temp) ==  :  missing value where TRUE/FALSE needed

Error in agreg.fit(X, Y, istrat, offset, init, control, weights = weights,  : exp overflow due to covariates

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