Raspberry I2C Error: Could not open file `/dev/i2c-1' or

Question

I have a problem in getting the I2C working on a Raspberry Zero 2 with Buster (10) 2022-09-22. The I2C interface is enabled (Preferences > Raspberry Pi Configuration > Interfaces).

If I run the command: i2cdetect -y 1

I get the error: Error: Could not open file `/dev/i2c-1' or...

Any suggestion?

Answer 1

Had the same problem, after a clean install with I2C on the ic2detection showed my sensor, then a python virtual environment setup and a reboot later, I go this error.

Turns out the raspi-config had I2C off in it and after sudo raspi-config and switching it on again, everything worked.