How to do randomization analysis (test) on TCR sequencing data?

Question

Recently I was doing some analysis on 10x TCR sequencing data.

But I was really confused because I don't know how to do it.

For example, I have TCR sequencing data like this data that I got from 10x https://cf.10xgenomics.com/samples/cell-vdj/6.0.1/SC5v2_humanPBMCs_5Kcells_Connect_single_channel_SC5v2_humanPBMCs_5Kcells_Connect_single_channel/SC5v2_humanPBMCs_5Kcells_Connect_single_channel_SC5v2_humanPBMCs_5Kcells_Connect_single_channel_vdj_t_filtered_contig_annotations.csv

Besides, the barcode information: https://cf.10xgenomics.com/samples/cell-vdj/6.0.1/SC5v2_humanPBMCs_5Kcells_Connect_single_channel_SC5v2_humanPBMCs_5Kcells_Connect_single_channel/SC5v2_humanPBMCs_5Kcells_Connect_single_channel_SC5v2_humanPBMCs_5Kcells_Connect_single_channel_count_sample_barcodes.csv

I want to do randomization on this data or on similar data.

How to do it in R ?

I know there is a package called boot in R but can't do something.

And if I have six groups of TCR data.

I can get the overlap of clonotypes between the six groups.

In order to make the overlap result better and get the significance for each overlapping number of clonotypes between groups, how to do the next ?

I don't know if what I am thinking is right or wrong. Could somebody give me some advice on my questions ?

Thanks in advance.